10 Best Isle of Palms Vacation Rentals

Best Overall: Stylish Beachfront Villa

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Best Oceanfront Condo: Isle of Palms Retreat

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Best Family Friendly: Spacious 3 Bed 3 Bath Oceanfront Condo

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Best Solo Studio: The Cozy Getaway

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Best for Big Groups: The Lucky Penny

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Best Luxury: Meadow Blu Beach House with Pool

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Best Villa: Beach Club Villa 32

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Best Penthouse: Artist's Palette

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Best Sea Cabin: Oceanfront Sea Cabin

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Best Private Home: Beachfront Vacation Home in Folly Beach

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When you purchase through links on our site, we may earn an affiliate commission. Images courtesy of Airbnb, VRBO Original Story By: Taylor Haught